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. 2020 Sep 18;8:552083. doi: 10.3389/fped.2020.552083

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Copyright © 2020 Balanza, Erice, Ngai, Varo, Kain and Bassat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Usefulness of a rapid triage “traffic light” test using host-based biomarkers for febrile children in low- and middle-income countries (LMICs). Febrile illnesses are among the most common causes for children to seek medical services in LMICs and their etiologies are diverse. Measuring host-based prognostic biomarkers for disease severity (e.g., angiopoietin-2 [Ang-2], soluble triggering receptor expressed on myeloid cells 1 [sTREM-1]) in febrile children could lead to objective child risk-stratification. Results of a rapid triage test at point-of-care would provide actionable results for health workers, guiding appropriate clinical decision-making. This has the potential to lead to better health outcomes as well as economic savings.