Table 1.
Potential inhibitors of the Nlrp3 inflammasome.
| Type | Nlrp3-targeting Agent | Tested in AD | Neuroprotection Observed | Sources |
|---|---|---|---|---|
| Direct Inhibitors | Ginsenoside Rg3 | N | –a | (73, 90) |
| JC-124 | Y | Y | (71) | |
| Oridonin | Y | Y | (91) | |
| Tranilast | N | – | (75) | |
| Indirect Inhibitors | Ketone bodies (i.e., BHB) | Y | Y | (92) |
| MCC950 | N | – | (80) | |
| Glyburide | N | – | (82) | |
| 16673-43-0 | N | – | (79) | |
| Autophagy-inducing | Resveratrol | N | – | (86) |
| HU-308 | N | – | (85) | |
| MicroRNAs | miR-223 | N | – | (87) |
| miR-9 | N | – | (88) |
a
Neuroprotection observations were not applicable in these studies.