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. 2020 Sep 2;14(10):2546–2559. doi: 10.1002/1878-0261.12783

Fig. 3.

Fig. 3

CX3CR1/Syk/PI3K is essential for CX3CL1‐induced platelet migration. (A) Platelet intracellular calcium flux was measured by Fluo3‐AM, and the fitting curves were shown (n = 3). (B) The analysis of platelet migration (n = 3, 1‐way ANOVA, mean ± SEM, **P < 0.01). (C) The expression of p‐Syk, Syk, p‐Akt, and Akt in platelet, and all the blots were derived from the same samples (n = 3, unpaired t‐test, 2‐tailed, mean ± SEM, *P < 0.05, **P < 0.01, NS, no significant difference). (D) HCC patients' platelet migration (n = 3, unpaired t‐test, 2‐tailed, mean ± SEM, *P < 0.05). (E) The expression of CX3CR1 in normal (N, n = 6) and HCC patients' platelets (P, n = 6), and the blots were derived from the same gel (unpaired t‐test, 2‐tailed, mean ± SEM, **P < 0.01).