Figure 1.

The frequency of monocyte subpopulations shift in patients with ALS. (A–E) The frequency of myeloid cell populations in the peripheral blood from healthy controls and ALS patients. (F–J) The frequency of myeloid cell populations correlated with patients’ ALSFRS-R score at the time of blood collection. ALSFRS-R scores are displayed from high to low to illustrate disease progression. Data are displayed in left plots as mean and SEM or in right plots with the best-fit line and 95% confidence intervals. R² value and P-value are also shown. Analysis performed with multivariable linear regression models controlling for age and sex, significant at P < 0.05 (*P = 0.021). CM/NCM, ratio of classical to non-classical monocytes.