Figure 4.
CD16 expression on neutrophils is associated with disease severity and rate of progression in ALS. The expression of CD16 on neutrophils was correlated with (A) disease severity and (B) rate of progression. ALSFRS-R scores are displayed from high to low to illustrate disease progression. Data are displayed with the best-fit line and 95% confidence intervals. R2 value and P-value are also shown. Analysis achieved with multivariable linear regression models, adjusted for age and sex, significant at P < 0.05. ΔALSFRS-R, rate of disease progression as measured by the change in ALSFRS-R over disease duration; MFI, median fluorescence intensity.