Figure 5.
Patients with ALS with impaired respiratory function have increased HLA-DR expression on monocyte subpopulations. HLA-DR expression on monocyte subpopulations was correlated with (A–C) SNIP (% predicted) and (D–F) FVC (% predicted). Data are displayed with the best-fit line and 95% confidence intervals. R2 value and P-value are also shown. Analysis achieved with multivariable linear regression models, adjusted for age and sex, significant at P < 0.05. MFI, median fluorescence intensity; SNIP, sniff nasal inspiratory pressure.