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. 2020 Sep 18;14:570583. doi: 10.3389/fncir.2020.570583

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Copyright © 2020 Alonso Martínez, Deco, Ter Horst and Cabral.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of significant between-group differences in PL states across partition models. (A) Each square in the matrix represents a PL state (or cluster) obtained for each k-means partition model with k varying between k = 4 and k = 14 (x-axis). PL states that are significantly different between low and high MDI (p-FDR < 0.05), either in terms of percentage of occupancy (o) or duration (d), are indicated by colored squares. Since significantly different PL states obtained for different k were found to represent variant forms of 3 underlying configurations of BOLD phase locking (see panel B), we used a color-code (blue, red, green) to illustrate how these different configurations occurred across k. (B) The cluster centroids, Vc, of significantly different PL states identified in panel A are represented as bar plots. Here, each horizontal bar represents the BOLD phase in each of the N = 223 brain regions projected into the corresponding leading eigenvector (captured by the N elements in Vc). The regions n whose BOLD signal is phase-shifted (Vc(n) > 0) were colored using the same color-code from panel A. MDI, Major Depression Inventory; PL, phase-locking.