FIGURE 1:

Kinetochore proteins are transcriptionally up-regulated after dendrite injury. (A) Schematic of experimental design for RNASeq assay. (B) Diagram of the mitotic kinetochore. Colors indicate distinct complexes: KMN network, blue; chromosome passenger complex (CPC), red; spindle assembly checkpoint (SAC), green; Rod-Zwilch-Zw10 complex (RZZ), light green; centromere-associated proteins, light blue. These colors correspond to kinetochore components in graphs throughout all the figures. (C) Average reads of kinetochore mRNA transcripts at baseline (left, gray) and 6 h after dendrite injury (right, colored). Averages and standard deviations are plotted on a log scale. N = 4 pools of 10 neurons each per condition. RNASeq data are included in Supplemental Table 1, and all data used to generate graphs are included in Supplemental Table 3.