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. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: J Struct Biol. 2020 Jul 28;212(1):107584. doi: 10.1016/j.jsb.2020.107584

Figure. 6 — Segmentation of secretory granules in 11 slices spaced by 1 μm through a β-cell: (A) mature granules, defined by wide halos (typically ≳100 nm) and angular-shaped (crystalline) cores; (B) immature granules, most commonly located in vicinity of trans-Golgi network, and defined by absence of halos and amorphous cores; (C) transforming immature granules, defined by narrow halos (typically ≲30 nm). Cell membrane is outlined in (A) and (B). Full width of each image = 15 μm

Figure. 6 — Segmentation of secretory granules in 11 slices spaced by 1 μm through a β-cell: (A) mature granules, defined by wide halos (typically ≳100 nm) and angular-shaped (crystalline) cores; (B) immature granules, most commonly located in vicinity of trans-Golgi network, and defined by absence of halos and amorphous cores; (C) transforming immature granules, defined by narrow halos (typically ≲30 nm). Cell membrane is outlined in (A) and (B). Full width of each image = 15 μm