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. 2020 Oct 1;10:16278. doi: 10.1038/s41598-020-73298-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Open area traveling in open field test. Time spent in open-area in 4-week old (A) and 8-week old (D) grouped male and female wild type (WT), F508del/F508del (CF), Hdac6-/-(HDA), and CF/HDA (DKO) mice. Significance determine by ANOVA with Newman–Kuels post-hoc test to compare groups; *p < 0.05 compared to WT control group, **p < 0.05 compared to CF test group. Replicates for each study are: (A) WT = 14, CF = 19, HDA = 19, DKO = 20; (B) WT = 20, CF = 21, HDA = 18, DKO = 16.