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. 2020 Oct 1;10:16257. doi: 10.1038/s41598-020-73212-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metformin enhances host resistance to Mtb. During acute, subacute, and chronic stages of infection lungs and spleens were harvested from euthanized, Mtb infected untreated- and metformin-treated guinea pigs to evaluate lesion burden (A, C) and bacterial burden (CFUs) (B, D). Stereo Investigator software was used to calculate the percent of lesion compared to total section area in guinea pig lungs and spleens (A, C). Percent lesion involvement was normalized to acute untreated. Colony forming units were generated by plating homogenized (C) lung or (D) spleen tissue on 7H11 agar plates and were quantified per gram of tissue. n = 7–12 animals per group per timepoint. Two outliers were found using Tukey IQR method (B). All outliers were greater than 2.0 times the IQR. Mann–Whitney test was used to determine significances between treatments within stage of infection *p ≤ 0.05.