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. 2020 Oct 1;10:16314. doi: 10.1038/s41598-020-73253-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Computational predictions of growth characteristics show good agreement with experimental reports. (A) The correlation between the experimental growth rate observed in previous studies and the in silico growth rate from Flux Balance Analysis (FBA) of iPN730. (B) The correlation between the experimental respiratory quotient (moles of carbon dioxide released per mole of oxygen consumed) and the in silico values obtained from iPN730. (C) The sensitivity analysis of the biomass objective function to variations in the coefficients of biomass precursors in iPN730.