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. 2020 Oct 1;10:16314. doi: 10.1038/s41598-020-73253-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Single knockout analysis of viability in rich and minimal media. (A) Radar plot for comparative analysis of the model in rich media with glucose, minimal media with glucose, minimal media with ethanol and minimal media with galactose for classifying essential and non-essential genes over multiple statistical parameters i.e. Accuracy, Sensitivity, Specificity, MCC and F₁ score. (B) Cross comparison between ground truth (Saccharomyces cerevisiae gene essentiality data) and the model predictions in the given media conditions. NG and G stands for No Growth and Growth respectively for each in silico knockout.