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. 2020 Oct 1;10:16218. doi: 10.1038/s41598-020-72480-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BRON treatment causes suppression of Notch target genes Hes1/Hey1 and cleaved Notch1 receptor protein in GSCs. (A) GSCs representing different activation levels of Notch1. (B) Identification of drug resistance in our cell models by RT-qPCR based quantification of suppression of Notch pathway targets (HES1 and HEY1) stratified our in vitro platform in responder (GBM1 and 407p) and non-responder (U87 and JHH) cells. We designated minimal drug concentration needed to achieve solid target gene suppression as 10 µg/ml for GBM1 and 1 µg/ml for 407p. (C) BRON treatment for 48 h caused significant reduction of cleaved Notch1 receptor protein in responder cells as compared to control/vehicle treatment condition.