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. 2020 Oct 1;10:16218. doi: 10.1038/s41598-020-72480-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Upregulation of WNT signals in response to BRON treatment. (A) Proteins in Notch and WNT pathways showed extensive interactions as revealed by co-occurrence of target genes in both pathways. Red dots represent proteins of the WNT network whereas blue dots represent members of the Notch signaling cascades. Yellow dots represented proteins in both Notch and WNT branch. (B) BRON treatment caused activation of expression of consensus WNT target genes (AXIN2, DVL2) and pathway reporter signals in GSCs. (C) Genetic suppression of WNT signaling with RNA interference against transcriptional pathway signal mediator beta-catenin (CTNNB1) caused induction of Hes1/Hey1 transcripts.