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. 2020 Sep 18;10:1495. doi: 10.3389/fonc.2020.01495

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Copyright © 2020 Han, Sun, Liu, Zhou, Zhang, Chen and Ba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GO and KEGG pathway analyses of downstream target genes of four downregulated miRNAs. (A-C): GO analysis. (A) Biological processes. (B) Cellular component. (C) Molecular function. (D) The top ten KEGG pathways enriched in the target genes. (E) The analysis of PI3K-Akt signaling pathway, MAPK signaling pathway, and pathways in cancer. (F) The identified target gene KRAS was measured by Western blot in CRC cell lines and tissues. P_S: chemosensitive CRC patients. P_R: chemoresistant CRC patients.