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MMP12 protein is upregulated in pulmonary granulomas of 60-day MWCNT-instilled C57BL/6 mice. Representative bright-field and immunofluorescence images for MMP12 protein indicate very minimal to no staining in PBS instilled mice, but increased protein around granulomas in MWCNT-instilled C57BL/6 at 60-days. Black aggregates in (lower left, red arrows) bright-field images are MWCNT accumulations in the tissue.
