Table 2.
Antithrombin III (AT) levels, anti-FXa levels, and thrombin generation values in plasma from healthy donors and trauma patients at baseline and following treatment with enoxaparin (0.13 U/mL). Number with percentage or median and IQR values are reported. Mann-Whitney tests were performed to determine statistical significance between groups.
| P-value | |||
|---|---|---|---|
| Baseline | |||
| Rate AT<80% | 0 | 20 (20%) | |
| AT (%) | 114 (109, 118) | 91 (78, 103)* | <0.01 |
| Lag time (min) | 5.0 (4.3, 5.7) | 4.3 (3.7, 5.0)* | <0.05 |
| Peak (nM) | 258 (153, 304) | 302 (254, 345)* | <0.01 |
| ttPeak (min) | 8.3 (7.0, 9.7) | 6.6 (6.0, 7.4)* | <0.01 |
| ETP (nM) | 1459 (1155, 1649) | 1492 (1237, 1713) | 0.38 |
| Rate (nM/min) | 67.8 (37.2, 107.7) | 129 (106, 156)* | <0.01 |
| Enoxaparin | |||
| Anti FXa levels (IU/mL) | 0.16 (0.14, 0.17) | 0.13 (0.12, 0.16)* | <0.01 |
| Rate Anti FXa>0.13 | 15 (100%) | 59 (59%)* | <0.01 |
| Delta Lagtime (%) | 6.6 (−4.3, 23) | 7.9 (0, 11) | 0.90 |
| Delta Peak (%) | −55 (−66, −36) | −24 (−32, −16)* | <0.01 |
| Delta ttPeak (%) | 17 (3.5, 36) | 12 (7.3, 17) | 0.20 |
| Delta ETP (%) | −43 (−48, −22) | −14 (−20, −9)* | <0.01 |
| Delta Rate (%) | −65 (−82, −57) | −39 (−51, −27)* | <0.01 |