Table 2.
Enrichment of TH-specific transcripts.
| DE transcript group | DE genes | Cell type | Overlapping genes | p-value | Adjusted p-value |
|---|---|---|---|---|---|
| CDT | 2,014 | TH1 | 150 | <1 × 10−5 | <8 × 10−5 |
| TH17 | 28 | 2.0 × 10−2 | 4.0 × 10−2 | ||
| OSE4sp | 2,362 | TH1 | 195 | <1 × 10−5 | <8 × 10−5 |
| TH17 | 36 | 2.0 × 10−3 | 8.0 × 10−3 | ||
| MOG4sp | 469 | TH1 | 35 | 1.1 × 10−2 | 3.3 × 10−2 |
| TH17 | 7 | 9.8 × 10−2 | 9.8 × 10−2 | ||
| OSE1ex | 693 | TH1 | 61 | 2.0 × 10−5 | 1.2 × 10−4 |
| TH17 | 16 | 1.0 × 10−3 | 5.0 × 10−3 |
1,080 TH1- and 145 TH17-specific transcripts were examined. P-values were computed using 100,000 permutations. Enrichments significant after Holm-Bonferroni correction for multiple testing (eight tests) are highlighted in bold font (adjusted p-value < 0.05). DE, differentially expressed; WT, wildtype; CDT, common disease transcripts (differentially expressed for both contrasts OSE4-OSE0 and MOG4-CFA but not in the two control contrasts OSE0-WT or CFA-WT); OSE4sp, OSE4-specific transcripts (differentially expressed for the contrast OSE4-OSE0 but not in MOG4-CFA, OSE0-WT, or CFA-WT); MOG4sp, MOG4-specific transcripts (differentially expressed for the contrast MOG4-CFA but not in OSE4-OSE0, OSE0-WT, or CFA-WT); OSE1ex, OSE1-expressed transcripts (differentially expressed in OSE1-OSE0 but not in OSE0-WT or CFA-WT).