Table 4.
The top 10 KEGG, WikiPathway, and Reactome terms enriched by the node genes
| Pathway | p-value | Node genes |
|---|---|---|
| KEGG | ||
| Chemokine signaling pathway | 2.67E−03 | CCL14;GNG8;CCL19;RASGRP2;GNG11 |
| Viral myocarditis | 3.22E−03 | CAV1;FYN;SGCG |
| Focal adhesion | 3.25E−03 | CAV2;CAV1;COL9A1;COL9A3;FYN |
| Proteoglycans in cancer | 3.39E−03 | WNT10A;MRAS;CAV2;CAV1;HSPB2 |
| Cytokine–cytokine receptor interaction | 3.60E−03 | EDAR;ACVRL1;CCL14;IL3RA;CCL19;GDF5 |
| Apelin signaling pathway | 4.97E−03 | MRAS;GNG8;PPARGC1A;GNG11 |
| Ras signaling pathway | 6.21E−03 | MRAS;GNG8;RASGRP2;GNG11;FGF21 |
| PI3K–Akt signaling pathway | 8.73E−03 | IL3RA;COL9A1;GNG8;COL9A3;GNG11;FGF21 |
| Protein digestion and absorption | 1.04E−02 | COL11A2;COL9A1;COL9A3 |
| Morphine addiction | 1.02E−02 | PDE2A;GNG8;GNG11 |
| WikiPathway | ||
| Preimplantation Embryo | 2.03E−04 | DNMT3L;SIX3;ZFP42;SOX8 |
| Gastric Cancer Network 2 | 4.92E−04 | PLAC8;COL9A1;COL9A3 |
| Adipogenesis | 4.13E−03 | NCOR2;KLF5;EBF1;PPARGC1A |
| Focal Adhesion-PI3K–Akt–mTOR-signaling pathway | 4.17E−03 | IL3RA;COL11A2;GNG8;PPARGC1A;GNG11;FGF21 |
| Mesodermal Commitment Pathway | 6.37E−03 | FOXC1;KLF5;SOX17;LEFTY2 |
| Differentiation of white and brown adipocyte | 6.89E−02 | PLAC8;PPARGC1A |
| PI3K–Akt Signaling Pathway | 7.23E−03 | IL3RA;COL9A1;GNG8;COL9A3;GNG11;FGF21 |
| Viral Acute Myocarditis | 8.62E−0.3 | CAV1;FYN;SGCG |
| Statin Pathway | 9.20E−03 | CETP;PDIA2 |
| Chemokine signaling pathway | 9.29E−03 | GNG8;CCL19;RASGRP2;GNG11 |
| Reactome | ||
| GPCR ligand binding Homo sapiens | 1.46E−05 |
WNT10A;NMB;S1PR1;GNG8;GPBAR1;AVPR1A; CCL19;RGR;INSL3;GNG11;SSTR3 |
| Class A/1 (Rhodopsin-like receptors) Homo sapiens | 2.18E−04 |
NMB;S1PR1;GPBAR1;AVPR1A;CCL19; RGR;INSL3;SSTR3 |
| Collagen biosynthesis and modifying enzymes Homo sapiens | 2.79E−04 | PCOLCE2;COL11A2;COL9A1;COL9A3 |
| Signal Transduction Homo sapiens | 3.73E−04 | NCF4;RASGRP2;RLBP1;CDH5;SOX17;S1PR1;GNG8;POLR2F;FYN;CCL19;INSL3;WNT10A;NMB;CAV1;PDE2A;GPBAR1;AVPR1A;S100B;GNG11;SSTR3;NCOR2;IL3RA;COL9A1;COL9A3;RGR |
| Extracellular matrix organization Homo sapiens | 5.50E−04 | ACAN;PCOLCE2;COL11A2;COL9A1;ICAM2;COL9A3;GDF5 |
| Transcriptional regulation of white adipocyte differentiation Homo sapiens | 6.63E−04 | NCOR2;KLF5;EBF1;PPARGC1A |
| G alpha (s) signaling events Homo sapiens | 7.37E−04 | PDE2A;GNG8;GPBAR1;INSL3;GNG11 |
| Collagen formation Homo sapiens | 8.74E−04 | PCOLCE2;COL11A2;COL9A1;COL9A3 |
| GPCR downstream signaling Homo sapiens | 1.21E−03 | NMB;PDE2A;GPBAR1;AVPR1A;RASGRP2;GNG11;SSTR3;IL3RA;S1PR1;GNG8;CCL19;RGR;INSL3 |
| G alpha (i) signaling events Homo sapiens | 1.31E−03 | S1PR1;GNG8;CCL19;RGR;GNG11;SSTR3 |