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. 2020 Oct 2;15:451. doi: 10.1186/s13018-020-01964-4

Table 3.

Mixed effects models for physical performance and self-reported measures (intention to treat analysis)

Variable LMEM time effect Timeagroup effect
PRE (N = 17) POST (N = 13) Δ (%) Parameter estimate (SE) t value
(p value)
Parameter estimate (SE) t value
(p value)
MViC extension (Nm/kg) Operated leg MIp 1.35 ± 0.41 0.80 ± 0.34

− 42.3

62.5

0.98 (0.08) 11.801 (< 0.001) − 0.42 (0.12) − 3.541 (0.001)
CON 1.55 ± 0.35 0.55 ± 0.25 − 62.5
Non-operated leg MIp 1.80 ± 0.39 1.77 ± 0.29 1.2 − 0.008 (0.042) − 0.205 (0.839) 0.008 (0.060) 0.129 (0.899)
CON 1.74 ± 0.44 1.66 ± 0.35 2.2
Voluntary muscle activation (%) Operated leg MIp 81.63 ± 12.48 84.84 ± 9.75 8.3 17.91 (5.10) 3.513 (0.001) − 21.26 (7.21) − 2.949 (0.006)
CON 82.42 ± 12.91 64.36 ± 20.85 − 16.7
Non-operated leg MIp 85.26 ± 9.23 81.42 ± 12.44 − 3.2 − 0.22 (3.98) − 0.056 (0.956) 4.05 (5.63) 0.720 (0.477)
CON 83.84 ± 8.78 84.08 ± 12.78 2.5
Knee flexion (degrees) Operated leg MIp 91.41 ± 12.81 82.31 ± 9.75 − 5.6 14.38 (4.50) 3.197 (0.03) − 5.79 (6.36) − 0.910 (0.370)
CON 86.76 ± 17.81 72.31 ± 14.28 − 13.2
Non-operated leg MIp 106.88 ± 9.64 106.54 ± 9.93 2.4 − 2.51 (2.91) − 0.862 (0.396) 1.71 (4.12) 0.416 (0.681)
CON 103.29 ± 12.16 106.77 ± 11.10 2.1
Knee extension (degrees) Operated leg MIp 4.12 ± 3.18 7.15 ± 3.74 45.9 − 3.20 (1.32) − 2.42 (0.022) 0.15 (1.87) 0.081 (0.936)
CON 3.18 ± 2.51 6.38 ± 4.56 101.3
Non-operated leg MIp 2.76 ± 1.79 2.15 ± 1.86 0.6 − 0.21 (0.75) − 0.28 (0.784) 0.88 (1.07) 0.823 (0.417)
CON 1.65 ± 1.66 1.92 ± 2.36 8.3
VAS score (points) Operated leg MIp 53.55 ± 12.84 31.54 ± 12.14 − 39.8 16.93 (4.32) 3.92 (0.001) 5.13 (6.11) 0.840 (0.408)
CON 54.12 ± 15.93 37.31 ± 14.67 − 27.3
Non-operated leg MIp 8.24 ± 8.83 1.54 ± 3.76 − 83.3 6.94 (2.26) 3.070 (0.004) − 0.12 (3.20) − 0.039 (0.970)
CON 13.82 ± 12.19 7.31 ± 13.01 − 56.0
Hand grip strength, dominant arm (kg) MIp 36.53 ± 12.92 38.85 ± 7.41 − 0.8 0.45 (1.15) 0.391 (0.699) − 0.13 (1.63) − 0.079 (0.937)
CON 40.24 ± 12.42 36.77 ± 11.41 2.7
TUG (s) MIp 7.72 ± 1.61 7.55 ± 1.22 4.0 − 4.02 (0.58)a − 6.960 (< 0.001) 4.04 (0.82) 4.952 (< 0.001)
CON 7.45 ± 1.51 11.54 ± 3.01 54.4
OKS score (points) MIp 23.12 ± 5.99 27.08 ± 5.17 28.3 − 3.22 (1.82)a − 1.767 (0.087) 5.27 (2.49) 2.116 (0.043)
CON 23.0 ± 7.44 20.08 ± 4.27 − 5.2

BMI Body mass index, MBI Magnitude-based inference, RDC Raw mean difference in change, Δ (%)–percent changes between initial and final measurement, SE Standard error, LMEM Linear mixed effects models p level of significance

aNegative direction of effect means better result on test;

Note: Data are presented as mean ± SD; Bold values represent a significant effect