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Stimulus response functions (SRF) of pressure pain. (A) Original data of SRF of pressure pain applied immediately before (TS1) and after (TS2) 1 min cold water immersion. (B) For multilevel data analysis, we used z-standardized pressure (for details, see description in “Materials and Methods” section). The CPM effect was defined as difference VASTS2 − VASTS1 during a z-standardized pressure of 0 (thick marked points). Thus, a negative value represents CPM-induced hypoalgesia.
