Table 2.

Significant changes in the levels of metabolites from polyamine synthesis pathways in synthesis and transport impaired pneumococci relative to the wild type (WT) strain.

Compounds	ΔspeA/TIGR4	ΔpotABCD/TIGR4
Agmatine	−21.1	−58.6
Arginine	n.s	−1.9
Cadaverine	n.s	n.s
Lysine	n.s	−1.9
Methionine	1.7	n.s
N-acetylspermidine	1.5	−8.2
N-acetylspermine	2.1	1.9
Ornithine	n.s	−1.6
Putrescine	n.s	−2.2
S-adenosylmethionine	n.s	−1.7
Spermidine	1.7	−58.7
Spermine	n.s	n.s

n.s = no significant difference at p ≤ 0.05. The magnitude of change in the ratio and the direction of change (i.e., positive for increase and negative for decrease) are shown. None of the metabolite concentrations in ΔspeE were found to be significantly different than those in strain TIGR4.