Table 1.
Characteristics of LSC cohort members by ethnicity
| Variable | Self-identified ethnicity | P value | |
|---|---|---|---|
| Hispanic | NHW | ||
| n | 327 | 1502 | |
| Age (years, mean ± SD) | 54.7 ± 8.8 | 57.7 ± 9.5 | 1.5 × 10−7a |
| Gender (male, %) | 24.5 | 22.0 | 0.34b |
| Current smokers (%) | 73.7 | 51.8 | 5.0 × 10−13b |
| Packyears (pys, median (Q1-Q3)) | 30.5 (23.0 – 40.2) | 36.0 (26.8 – 50.2) | <0.0001c |
| 10–26 (%) | 33.0 | 21.9 | 3.8 × 10−6b |
| 26–37 (%) | 33.0 | 30.8 | |
| 37–145 (%) | 33.9 | 47.3 | |
| BMI (kg/m2, mean ± SD) | 29.1 ± 6.1 | 27.9 ± 6.0 | 0.0027a |
| 16–25 (%) | 25.1 | 34.2 | 0.0063b |
| 25–30 (%) | 40.4 | 36.0 | |
| 30–61 (%) | 34.6 | 29.8 | |
| Education level (%) | |||
| Less than college | 53.9 | 24.2 | 2.5 × 10−26b |
| Some college or above | 46.2 | 75.8 | |
| Ancestry component (mean ± SD) | |||
| European ancestry | 0.64 ± 0.08 | 0.97 ± 0.03 | NCd |
| Native American ancestry | 0.34 ± 0.08 | 0.03 ± 0.02 | NCd |
| African ancestry | 0.02 ± 0.02 | 0.00 ± 0.01 | NCd |
| Promoter methylation in sputum (%)e | |||
| P16 | 19.4 | 20.2 | 0.77 |
| MGMT | 26.5 | 25.3 | 0.69 |
| RASSF1A | 0.4 | 0.9 | 0.41 |
| DAPK | 19.8 | 15.5 | 0.091 |
| GATA4 | 41.8 | 35.0 | 0.036 |
| GATA5 | 19.8 | 14.2 | 0.021 |
| PAX5α | 12.3 | 14.8 | 0.30 |
| PAX5β | 8.6 | 8.0 | 0.77 |
| SULF2 | 42.9 | 33.3 | 0.0028 |
| PCDH20 | 41.8 | 34.4 | 0.022 |
| DAL1 | 7.8 | 6.7 | 0.49 |
| JPH3 | 21.3 | 22.3 | 0.72 |
| Number of unanswered food items (median (Q1-Q3)) | 0 (0 – 3) | 0 (0 – 2) | 0.0064c |
| Total calorie intake (kcal) (median (Q1-Q3)) | 1782.4 (1361.1 – 2353.5) | 1714.9 (1339.9 – 2148.9) | 0.067c |
| rs1801133 genotypef | |||
| CC | 0.34 | 0.45 | 0.0069b |
| CT | 0.51 | 0.43 | |
| TT | 0.16 | 0.12 | |
a
Student’s t-test.
b
x2 test.
c
Wilcoxon rank sum test.
d
Not calculated. Ancestry analysis included 307 Hispanics and 1390 NHW.
e
Methylation data is complete for 268 Hispanics and 1158 NHW.
f
CC, CT, and TT genotype of rs1801133 were coded as 0, 1, and 2 in the statistical analysis.