Table 2.
Individual nutrients associated with risk for methylation in 268 Hispanics and 1158 NHWsa
| Nutrient (unit/d) | OR (95% CI)b | Praw | PFDR | Mean ± SD | Median (Q1 - Q3) |
|---|---|---|---|---|---|
| Vitamin B12 (μg) | 0.98 (0.97 – 0.99) | 0.00035 | 0.050 | 27.17 ± 78.43 | 10.54 (5.86 – 19.67) |
| Manganese (mg) | 0.89 (0.82 – 0.96) | 0.0015 | 0.095 | 4.54 ± 2.59 | 3.94 (2.70 – 5.91) |
| Proline (g)c | 1.25 (1.08 – 1.44) | 0.002 | 0.095 | 4.89 ± 1.93 | 4.64 (3.51 – 5.97) |
| Total Trans/Cis Trans Linoleic (g)c | 1.18 (1.06 – 1.31) | 0.0032 | 0.095 | 0.44 ± 0.23 | 0.39 (0.28 – 0.55) |
| Sodium (g) | 1.22 (1.07 – 1.40) | 0.0034 | 0.095 | 2.19 ± 0.86 | 2.07 (1.58 – 2.68) |
| Saturated fat (g) | 1.19 (1.06 – 1.35) | 0.0045 | 0.095 | 23.80 ± 10.40 | 22.03 (16.38 – 29.59) |
| Animal fat (g) | 1.15 (1.04 – 1.27) | 0.0047 | 0.095 | 35.14 ± 17.02 | 32.72 (22.60 – 44.31) |
| Palmitic fatty acid (g) | 1.21 (1.06 – 1.38) | 0.0056 | 0.099 | 13.31 ± 5.65 | 12.41 (9.22 – 16.62) |
| Manganese without supplements (mg) | 0.88 (0.80 – 0.96) | 0.0064 | 0.101 | 3.39 ± 1.58 | 3.20 (2.22 – 4.22) |
| c9, t11 conjugate diene isomer 18:2 Linoleic (mg)c | 1.17 (1.04 – 1.31) | 0.0072 | 0.102 | 105.85 ± 57.76 | 96.15 (64.14 – 135.3) |
| Stearic fatty acid (g) | 1.17 (1.04 – 1.32) | 0.0084 | 0.109 | 5.99 ± 2.70 | 5.58 (4.04 – 7.42) |
| Magnesium (mg) | 0.88 (0.80 – 0.97) | 0.010 | 0.119 | 345.95 ± 137.42 | 328.79 (248.52 – 423.16) |
| Vitamin D (IU) | 0.91 (0.84 – 0.98) | 0.011 | 0.120 | 477.13 ± 373.18 | 455.08 (154.12 – 623.01) |
| Myristic fatty acid (g) | 1.12 (1.02 – 1.22) | 0.014 | 0.136 | 1.94 ± 1.06 | 1.74 (1.17 – 2.48) |
| Palmitelaidic trans fatty acid (g)c | 1.18 (1.03 – 1.34) | 0.014 | 0.136 | 0.09 ± 0.05 | 0.08 (0.05 – 0.12) |
| Total Trans (g)c | 1.17 (1.03 – 1.32) | 0.016 | 0.140 | 2.37 ± 1.18 | 2.16 (1.5 – 2.97) |
| Niacin (mg) | 0.96 (0.92 – 1.00) | 0.020 | 0.140 | 40.18 ± 36.86 | 33.56 (21.26 – 46.05) |
| Total folate intake (μg) | 0.91 (0.83 – 0.99) | 0.021 | 0.140 | 637.34 ± 343.80 | 603.57 (351.12 – 829.65) |
a
Methylation data is complete for 268 Hispanics and 1158 NHW.
b
Unit for calculating the OR is the difference between Q3 and Q1. Age, sex, ethnicity, smoking history (smoking status and packyears), BMI, and total calorie intake were included in the GEE models for covariate adjustment.
c
38% study subjects have missing data for these nutrients.