Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram showing mechanism of MyD88 adopter-mediated surface TLR3 signaling. The diagram illustrating how TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] induces the recruitment of the MyD88 complex and activation of downstream signaling cascade. Downstream activation of IRAK-1, TAK1, TRAF6, and TAB1 enables translocation of NF-κB, p65 to the nucleus to induce the secretion of proinflammatory cytokine IL-6 that induces cell proliferation via cyclin D1.
