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. 2020 Sep 17;10:554313. doi: 10.3389/fonc.2020.554313

Figure 1.

Figure 1

Mechanisms of cancer cell mediated immune escape. Antigen presenting cells (APCs) absorb antigens released by cancer cells and present them to T cells to promote T cells activation and high expression of PD-1. Upon T cell activation, the PD-1 receptor binds to PD-L1/PD-L2 expressed on the surface of cancer cells and suppresses the immune response. In addition, tumor cells can also present antigens directly to activated T cells in the context of MHC. Anti-PD-1/PD-L1 antibodies can block the above process and enhance the body's immune response.