Figure 2. Synchronous and asynchronous attractors recovered from computational simulation of the eBCRN.

(A) Attractors labeled according to their compatibility with cellular stages of B lymphopoiesis. Particular lymphoid markers used for this classification are highlighted in bold. The transition between the identified phenotypes resembles in vivo events occuring during B cell differentiation within the bone marrow. (B) Transitions between attractors induced by one-bit flip perturbations (0 to 1, 1 to 0) occur in the same direction as in the differentiation process.