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. 2020 Sep 29;8:e9902. doi: 10.7717/peerj.9902

Figure 4. NFκB constitutive activation induces the arrest of aberrant phenotypes in the B cell differentiation pathway.

Figure 4

(A) Continuous simulation of NFkB eBCR mutant networks including node knock-out (NFkB = 0) and two levels of constitutive activation (OA, overactivation: NFkB = 1, and int, intermediate: NFkB = 0.5). (B) and (D) Representative nodes in NFkB OA and int mutated eBCRN, respectively. (C) Induction of an intermediate value of NFkB at different developmental stages derive in different attractors, some remaining unperturbed and reaching the immature B cell phenotype, and some arresting the simulation at an aberrant pre-B like phenotype. Above the developmental stage where the NFkB intermediate value was induced (i.e., LMPP, CLP, PreB and Imm B), are indicated the number of stages of the cyclic attractors reaching the immature B (Imm B) stage and the number of stages redirecting the simulation to an aberrant pre-B like phenotype (CXCR7+Pre-B like). FP: Fixed point attractor.