Table 3.
Associations between Baseline Levels of Kidney Function Indicators with Secondary Outcomes under the Mixed-Effects Cox Model
| Secondary outcomes | Elevated BUN |
Elevated Scr |
Decreased BUA |
|||
|---|---|---|---|---|---|---|
| HR (95% CI)a | pb | HR (95% CI)a | pb | HR (95% CI)a | pb | |
| Septic shock | 4.80 (3.74–6.17) | <0.001 | 2.26 (1.66–3.08) | <0.001 | 2.31 (1.79–2.98) | <0.001 |
| DIC | 4.49 (2.91–6.94) | <0.001 | 2.11 (1.24–3.57) | 0.006 | 2.10 (1.31–3.36) | 0.002 |
| ARDS | 3.11 (2.76–3.51) | <0.001 | 1.67 (1.45–1.94) | <0.001 | 2.17 (1.95–2.43) | <0.001 |
ARDS, acute respiratory distress syndrome; BUA, blood uric acid; BUN, blood urea nitrogen; CI, confidence interval; DIC, disseminated intravascular coagulation; HR, hazard ratio; Scr, serum creatinine. “Elevated” indicates above the upper limit of normal; “decreased” indicates below the lower limit of normal.
a
In the mixed-effects Cox model, adjusted variables included age, gender, and comorbidities (hypertension, coronary heart disease, diabetes), and hospital site was treated as a random effect.
b
The p values were calculated based on the mixed-effects Cox model.