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. 2020 Aug 14;12(1):1802135. doi: 10.1080/19420862.2020.1802135

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Visualization of IgG1-FcRn complex by negative stain electron microscopy. Six representative classifications of IgG1 and IgG1-FcRn complex are shown. FcRn is highlighted with yellow arrows/circles. (a) IgG1 alone in a canonical Y-shaped conformation. (b) IgG1 in a T-shaped conformation and binds to FcRn at 1:1 stoichiometry. (c) IgG1 in a Y/T mixed conformation and binds to FcRn at 1:1 stoichiometry. (d) IgG1 in a canonical Y-shaped conformation and binds to FcRn at 1:1 stoichiometry. (e) IgG1 in a T-shaped conformation and binds to FcRn at 1:2 stoichiometry. (f) IgG1 in a Y/T mixed conformation and binds to FcRn at 1:2 stoichiometry.