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FcRn affinity to Ag-IgG1 complexes.
| Sample | Antigen Sequence | ka (1/Ms) | kd (1/s) | KD (M) | Change (%), N = 2 |
|---|---|---|---|---|---|
| IgG1 unbound | No Antigen | 6.15E+05 | 0.5798 | 9.43E-07 | 76 ± 18% |
| IgG1 + Ag-WT | GGGS-Ag-GGGS | 2.91E+05 | 0.1971 | 6.78E-07 | Ctrl (100 ± 3%) |
| IgG1 + Ag-R | RGGGS-Ag-GGGR | 3.88E+05 | 0.1099 | 2.83E-07 | 239 ± 11% |
| IgG1 + Ag-W | WGGGS-Ag-GGGSW | 4.70E+05 | 0.0917 | 1.95E-07 | 349 ± 2% |
| IgG1 + Ag-D | DGGGS-Ag-GGGD | 2.84E+05 | 0.2309 | 8.14E-07 | 83 ± 0% |
