Table 3.
Genes expression in Cortex of sham and mTBI mice.
| Gene | Tissue | Treat | Time post mTBI | P value | ||||
|---|---|---|---|---|---|---|---|---|
| Week 10 | Week 19 | Week 28 | TBI effect | Time effect | TBI X time interaction | |||
| HK1 | Contralateral cortex | Sham | 100.0 ± 8.7 | 87.8 ± 8.2 | 55.3 ± 3.0 | <0.01 | ||
| mTBI | 92.9 ± 6.6 | 67.5 ± 4.3 | 57.5 ± 3.1 | |||||
| Ipsilateral cortex | Sham | 103.2 ± 8.6 | 108.1 ± 7.0 | 97.7 ± 4.0 | ||||
| mTBI | 101.4 ± 8.5 | 102.2 ± 6.7 | 87.9 ± 7.6 | |||||
| PFK | Contralateral cortex | Sham | 100.0 ± 3.0 | 109.9 ± 6.3 | 95.0 ± 3.6 | <0.05 | ||
| mTBI | 95.7 ± 5.5 | 90.1 ± 2.2** | 97.2 ± 2.0 | |||||
| Ipsilateral cortex | Sham | 98.3 ± 5.0 | 95.8 ± 4.1 | 102.9 ± 2.7 | ||||
| mTBI | 107.2 ± 3.9 | 89.5 ± 10.7 | 99.2 ± 5.3 | |||||
| PK | Contralateral cortex | Sham | 100.0 ± 5.3 | 103.5 ± 4.6 | 111.6 ± 3.9 | <0.01 | ||
| mTBI | 97.0 ± 5.9 | 97.1 ± 3.5 | 112.5 ± 3.7 | |||||
| Ipsilateral cortex | Sham | 90.3 ± 5.0 | 103.1 ± 2.9 | 104.0 ± 5.4 | ||||
| mTBI | 96.5 ± 4.4 | 104.0 ± 5.5 | 103.1 ± 5.1 | |||||
| PDH | Contralateral cortex | Sham | 100.0 ± 9.0 | 88.2 ± 7.4 | 71.5 ± 4.9 | <0.01 | ||
| mTBI | 86.5 ± 8.8 | 67.9 ± 3.7 | 72.3 ± 4.7 | |||||
| Ipsilateral cortex | Sham | 98.4 ± 9.3 | 93.1 ± 6.5 | 98.8 ± 4.5 | ||||
| mTBI | 95.9 ± 8.7 | 96.2 ± 5.3 | 88.4 ± 6.7 | |||||
| Glut-1 | Contralateral cortex | Sham | 100.0 ± 5.3 | 86.3 ± 5.8 | 100.9 ± 5.2 | <0.05 | ||
| mTBI | 90.0 ± 4.0 | 83.2 ± 2.5 | 96.5 ± 4.5 | |||||
| Ipsilateral cortex | Sham | 89.0 ± 3.2 | 91.5 ± 6.8 | 89.5 ± 3.8 | ||||
| mTBI | 90.6 ± 3.8 | 93.0 ± 6.5 | 87.2 ± 5.3 | |||||
| Glut-3 | Contralateral cortex | Sham | 100.0 ± 6.3 | 89.2 ± 4.4 | 68.0 ± 3.2 | <0.01 | ||
| mTBI | 88.3 ± 5.2 | 78.8 ± 3.3 | 71.3 ± 3.2 | |||||
| Ipsilateral cortex | Sham | 90.8 ± 3.7 | 92.0 ± 5.6 | 89.1 ± 3.7 | <0.05 | |||
| mTBI | 92.2 ± 5.7 | 100.3 ± 7.3 | 76.4 ± 5.0 | |||||
| MCT-1 | Contralateral cortex | Sham | 100.0 ± 14.7 | 78.9 ± 8.0 | 101.9 ± 10.1 | |||
| mTBI | 78.0 ± 5.8 | 93.5 ± 4.5 | 81.8 ± 4.3 | |||||
| Ipsilateral cortex | Sham | 82.0 ± 5.1 | 86.0 ± 8.8 | 91.8 ± 6.3 | <0.05 | |||
| mTBI | 86.4 ± 5.8 | 97.2 ± 12.0 | 66.2 ± 5.5** | |||||
| MCT-2 | Contralateral cortex | Sham | 100.0 ± 7.2 | 74.2 ± 4.0 | 62.9 ± 8.0 | <0.01 | ||
| mTBI | 101.6 ± 5.4 | 67.9 ± 4.4 | 54.5 ± 8.1 | |||||
| Ipsilateral cortex | Sham | 94.4 ± 9.9 | 73.9 ± 10.9 | 69.8 ± 4.4 | <0.05 | |||
| mTBI | 85.1 ± 6.9 | 73.2 ± 9.2 | 60.6 ± 6.0 | |||||
| HK2 | Contralateral cortex | Sham | 100.0 ± 6.5 | 90.5 ± 10.9 | 59.8 ± 3.6 | <0.01 | ||
| mTBI | 83.4 ± 11.5 | 83.4 ± 10.8 | 60.4 ± 3.2 | |||||
| Ipsilateral cortex | Sham | 77.8 ± 7.8 | 95.2 ± 10.3 | 98.3 ± 5.0 | <0.05 | <0.05 | ||
| mTBI | 90.8 ± 8.2 | 112.9 ± 12.8 | 69.9 ± 6.5** | |||||
| GPR81 | Contralateral cortex | Sham | 100.0 ± 19.3 | 90.5 ± 15.8 | 60.2 ± 7.1 | <0.01 | ||
| mTBI | 122.1 ± 23.3 | 80.3 ± 11.2 | 54.6 ± 8.3 | |||||
| Ipsilateral cortex | Sham | 94.5 ± 15.2 | 110.5 ± 16.4 | 69.4 ± 12.8 | <0.01 | |||
| mTBI | 84.3 ± 17.2 | 121.7 ± 18.3 | 54.3 ± 9.6 | |||||
Data are presented as % change of expression level relative to the contralateral side of the cortex in the sham group measured at week 10 post mTBI.
Data are mean ± SE (n = 9–10/group).
P Value: Obtained from Two-Way ANOVA analysis. If P>0.05, the value is not listed on the table.
**
P < 0.01 when compared with the Sham group at the same injury sides and same time point by T-test.