Table 4.
Genes expression in hypothalamus of sham and mTBI mice.
| Gene | Treat | Time post mTBI | P value | ||||
|---|---|---|---|---|---|---|---|
| Week 10 | Week 19 | Week 28 | TBI effect | Time effect | Interaction | ||
| HK1 | Sham | 100.0 ± 3.0 | 114.2 ± 5.8 | 91.2 ± 7.7 | <0.01 | ||
| mTBI | 102.9 ± 4.0 | 110.8 ± 4.0 | 100.6 ± 3.4 | ||||
| PFK | Sham | 100.0 ± 3.5 | 112.4 ± 3.8 | 84.8 ± 6.9 | <0.01 | ||
| mTBI | 98.2 ± 3.2 | 103.6 ± 3.6 | 94.3 ± 2.2 | ||||
| PK | Sham | 100.0 ± 8.1 | 89.6 ± 7.5 | 73.1 ± 6.2 | <0.01 | ||
| mTBI | 101.9 ± 4.9 | 98.2 ± 5.3 | 83.5 ± 6.1 | ||||
| PDH | Sham | 100.0 ± 7.3 | 95.2 ± 6.1 | 91.7 ± 4.8 | |||
| mTBI | 94.9 ± 6.0 | 87.4 ± 6.3 | 78.3 ± 3.4 | ||||
| Glut-1 | Sham | 100.0 ± 3.8 | 119.9 ± 7.4 | 100.7 ± 3.4 | |||
| mTBI | 104.1 ± 4.8 | 108.1 ± 6.9 | 105.7 ± 6.9 | ||||
| Glut-3 | Sham | 100.0 ± 3.1 | 114.2 ± 4.0 | 100.5 ± 3.8 | <0.05 | ||
| mTBI | 101.0 ± 4.4 | 106.8 ± 4.2 | 104.3 ± 2.5 | ||||
| MCT-1 | Sham | 100.0 ± 5.3 | 120.2 ± 4.0 | 98.1 ± 8.2 | |||
| mTBI | 112.6 ± 4.8 | 113.4 ± 8.8 | 108.2 ± 3.8 | ||||
| MCT-2 | Sham | 100.0 ± 6.2 | 114.9 ± 6.9 | 98.5 ± 6.8 | <0.01 | ||
| mTBI | 104.8 ± 4.2 | 125.8 ± 9.9 | 100.9 ± 3.9 | ||||
| HK2 | Sham | 100.0 ± 9.1 | 103.9 ± 8.4 | 76.7 ± 3.5 | <0.01 | <0.05 | |
| mTBI | 120.4 ± 9.4 | 127.0 ± 6.5 | 115.9 ± 6.6 | ||||
| GPR 81 | Sham | 100.0 ± 22.6 | 84.7 ± 10.4 | 104.4 ± 14.7 | |||
| mTBI | 101.7 ± 10.8 | 88.3 ± 14.9 | 86.4 ± 12.7 | ||||
Data are presented as % change of expression level in the hypothalamus of the sham group measured at week 10 post mTBI.
Data are mean ± SE (n = 9-10/group).
P Value: Obtained from Two-Way ANOVA analysis. If P > 0.05, the value is not listed on the table.