Table 5.
Genes expression in brainstem of sham and mTBI mice.
| Gene | Treat | Time post mTBI | P value | ||||
|---|---|---|---|---|---|---|---|
| Week 10 | Week 19 | Week 28 | TBI effect | Time effect | Interaction | ||
| HK1 | Sham | 100.0 ± 10.2 | 117.3 ± 11.2 | 95.7 ± 5.9 | |||
| mTBI | 114.1 ± 13.2 | 107.7 ± 5.1 | 97.7 ± 4.5 | ||||
| PFK | Sham | 100.0 ± 6.6 | 109.8 ± 6.4 | 109.3 ± 4.2 | |||
| mTBI | 108.9 ± 6.42 | 113.71 ± 4.5 | 114.9 ± 5.1 | ||||
| PK | Sham | 100.0 ± 8.5 | 93.3 ± 5.0 | 86.1 ± 4.1 | <0.01 | ||
| mTBI | 105.8 ± 5.8 | 100.7 ± 5.0 | 86.6 ± 4.3 | ||||
| PDH | Sham | 100.0 ± 6.2 | 94.6 ± 3.6 | 86.1 ± 6.1 | <0.05 | ||
| mTBI | 115.0 ± 9.2 | 94.5 ± 5.7 | 99.8 ± 5.4 | ||||
| Glut-1 | Sham | 100.0 ± 8.0 | 107.2 ± 6.1 | 73.7 ± 3.5 | <0.01 | ||
| mTBI | 100.3 ± 8.5 | 99.2 ± 4.0 | 74.9 ± 3.6 | ||||
| Glut-3 | Sham | 100.0 ± 9.6 | 107.1 ± 7.0 | 81.2 ± 4.4 | <0.01 | ||
| mTBI | 105.9 ± 6.6 | 94.5 ± 2.7 | 86.7 ± 2.5 | ||||
| MCT-1 | Sham | 100.0 ± 8.2 | 115.5 ± 10.1 | 86.7 ± 5.6 | <0.01 | ||
| mTBI | 108.3 ± 6.7 | 116.9 ± 6.9 | 97.2 ± 5.8 | ||||
| MCT-2 | Sham | 100.0 ± 15.8 | 102.4 ± 17.8 | 64.8 ± 3.5 | <0.01 | ||
| mTBI | 118.4 ± 12.1 | 87.6 ± 6.9 | 76.5 ± 6.5 | ||||
| HK2 | Sham | 100.0 ± 9.9 | 97.8 ± 15.9 | 86.1 ± 4.0 | <0.05 | <0.05 | |
| mTBI | 130.7 ± 14.4 | 134.6 ± 13.8 | 92.1 ± 5.8 | ||||
| GPR 81 | Sham | 100.0 ± 19.5 | 94.7 ± 21.2 | 63.8 ± 13.9 | <0.01 | <0.01 | |
| mTBI | 225.2 ± 35.2 | 154.8 ± 23.1 | 97.87 ± 21.9 | ||||
Data are presented as % change of expression level in the brainstem of the sham group measured at week 10 post mTBI.
Data are mean ± SE (n = 9-10/group).
P Value: Obtained from Two-Way ANOVA analysis. If P > 0.05, the value is not listed on the table.