Figure 1.

Relative stability of IgGs toward reduction by the thioredoxin system. IgG1, IgG2, and IgG4 mAbs were incubated with the components of the thioredoxin system. The figure contains data for 4 distinct IgG1s, 3 distinct IgG4s, and 2 distinct IgG2s. Samples were taken at the indicated timepoints and intact mAb was quantified using capillary electrophoresis. Experiment was repeated twice with single replicates; 1 replicate is shown.