Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The relative stability of the IgG4λs was assessed by fitting the results in Figure 4 to a first-order exponential decay to determine the half-life of each mAb. An IgG1λ and IgG2λ were included for comparison
| IgG4 Hinge Region Mutation(s) | 50% Reduced (min) | Fold Improvement |
|---|---|---|
| Unmodified | 12.3 | NA |
| Y219 C | 15.9 | 1.3 |
| G220 C | 27.5 | 2.2 |
| S228P | 37.3 | 3.0 |
| Y219 C+ S228P | 44.0 | 3.6 |
| G220 C+ S228P | 59.0 | 4.8 |
| Y219 C+ G220 C | 32.1 | 2.6 |
| Y219 C+ G220 C+ S228P | 83.9 | 6.8 |
| IgG1λ | 3.2 | 0.3 |
| IgG2λ | 41.7 | 3.4 |
