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. 2020 Sep 24;12(1):1813962. doi: 10.1080/19420862.2020.1813962

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Scheme of mPBPK/TE model for the CNTO 5048 interaction with TNF in serum and colon. (a) Basic second-generation minimal PBPK was used to characterize serum CNTO 5048 pharmacokinetics; (b) Colon compartments were incorporated into the basic mPBPK model to characterize colon CNTO 5048 distribution; (c) TMDD in the serum compartment was integrated into Model B to characterize the free TNF profile in serum; and (d) TMDD in the colon compartment was added to Model C to characterize the free TNF dynamics in colon.