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. 2020 May 25;12(1):1763727. doi: 10.1080/19420862.2020.1763727

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© 2020 Bristol Myers Squibb. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Viable cell density (VCD) and viability profiles for six monoclonal antibodies (A-F: mAb-A to mAb-F) between RCB, Tox, and FIH stages. RCB was at 5 L scale with individual 6 clones (RCBs), Tox was at 200 L scale with a pool of 6 clones (RCBs), and FIH was at 1,000 L scale with the lead clone MCB. Two expression systems were used: mAb-A, B, C with a CHO DG44 system, mAb-D, E, F with a CHO K1 system. RCB: Research Cell Bank; MCB: Master Cell Bank; FIH: First-in-Human. Solid symbols represent VCD profiles and open symbols represent viability profiles. For RCB, error bars represent the spread of all 6 clones (n = 6). For FIH, error bars represent one standard deviation of multiple FIH batches (n = 3–6). Only one batch was produced for Tox (n = 1).