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Final titer profiles for six monoclonal antibodies (mAb-A to mAb-F) between RCB, Tox, and FIH stages. RCB was at 5 L scale with individual 6 clones (RCBs), Tox was at 200 L scale with a pool of 6 clones (RCBs), and FIH was at 1,000 L scale with the lead clone. RCB: Research Cell Bank; FIH: First-in-Human. For FIH, error bars represent one standard deviation of multiple FIH batches (n = 3–6).
