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. 2020 May 25;12(1):1763727. doi: 10.1080/19420862.2020.1763727

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© 2020 Bristol Myers Squibb. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Quality attributes for six mAbs (mAb-A to mAb-F) between RCB, Tox, and FIH stages. RCB was at 5 L scale with individual 6 clones (RCBs), Tox was at 200 L scale with a pool of 6 clones (RCBs), and FIH was at 1,000 L scale with the lead clone. (a) Charge variants: acidic variants, main, and basic variants; (b) HMW and Monomer; (c) Major N-linked glycans: G1F, G2F, and Man5. RCB: Research Cell Bank; FIH: First-in-Human; HMW: High molecular weight. For RCB, error bars represent the spread of all 6 clones (n = 6). For FIH, error bars represent one standard deviation of multiple batches (n = 3–6).