Table 1.

Process changes between Tox and FIH batches ^a.

Molecule	Media Changes b	Process Setpoint Changes
mAb-A	No	No
mAb-B	Basal Feed	Inoculation density Feed volume Feeding Strategy
mAb-C	Basal	Inoculation density pH setpoint Feeding Strategy
mAb-D	No	No
mAb-E	Feed	Feeding Strategy
mAb-F	No	No

a. Process changes were for productivity and/or quality considerations.

b. Media changes were limited to implementation of different versions of BMS platform media, in which main components were the same.