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C0021158 inhibits recombinant ARG2 with a noncompetitive mechanism of action. The activity of trimeric ARG2 was measured at defined concentrations of C0021158 IgG1 while titrating different concentrations of L-arginine into the assay. Changing the concentration of C0021158 reduces the enzyme’s Vmax without significantly affecting its KM. Michaelis-Menten least squares fit model used to determine Vmax and KM values for a given concentration of C0021158 (Table 1).
