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. 2020 Jun 16;12(1):1770018. doi: 10.1080/19420862.2020.1770018

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© 2020 The Author(s). Published by Taylor & Francis.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (a) Schematic representation of the TMDD-based PK/TE model. The model parameter names are as defined in Materials and Methods. (b) Observed serum concentrations versus time profiles of Total TNF following 14 weekly high doses of golimumab, golimumab + CNTO 6785 or JNJ-8104 in cynomolgus monkeys. (c) Observed (symbols) and model-predicted (dashed lines) serum concentrations versus time profiles of Total TNF following high doses of golimumab or JNJ-8104 in cynomolgus monkeys. Data are represented as mean ± SD.