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. 2020 Sep 17;12(1):1816312. doi: 10.1080/19420862.2020.1816312

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Views of the variable region of mAbC. (a) Coloring indicates SCM values, with red coloring indicating exposed negative charge. (b)-(d) Coloring indicates local Γ₂₃ values for proline, Arg.HCl, and NaCl, respectively, with bulk excipient concentrations of 0.15 m. Red indicates preferential inclusion. All three excipients show some positive interactions with at least part of the negatively charged patch shown in (A). Views are of the Fv domain, side-on, as indicated by the eyeball in the inset, so that the figures include all complementarity-determining regions.