Figure 7.

Views of a portion of the mAbC Fv. (a) is colored by the SAP score, with red indicating exposed hydrophobicity. (b) and (c) are colored by the local ${\mathrm{\Gamma }}_{23}$ values with Arg.HCl and NaCl, respectively, with red indicating inclusion. Values are taken from simulations with bulk excipient concentrations of 0.15 m. Arg.HCl is net included in the circled high-SAP patch ($0.07\pm 0.03$), while NaCl is net excluded from this patch ($-0.08\pm 0.03$). Views are of the Fv domain, side-on, so that the figures include all complementarity-determining regions, albeit from a slightly higher angle than in Figure 6 so as to view the whole high-SAP region, circled.