Figure 3.

Lesion locations associated with depression intersect a brain circuit derived from independent lesion datasets. (A) The analysis shown in figure 2B was repeated five times, each time leaving out one of the five datasets. In all five analyses, a similar region in the left dorsolateral prefrontal cortex was significantly more connected to lesions of depressed subjects than to lesions of non-depressed subjects (depicted in red; voxel-level family-wise error [FWE] corrected p < 0.05). (B) and (C) The functional connectivity of each of these regions to the remainder of the brain was computed using a normative connective of 1000 healthy subjects, generating five depression circuits. The red-yellow and blue-cyan coloration depict positive connectivity and negative connectivity (anti-correlation) to the region, respectively, while green coloration depicts sample lesion locations from the excluded dataset. Depression circuits are thresholded at T = ±5 for ease of visualization (actual depression circuits for analysis are unthresholded). (D) Network damage scores, representing intersection of each lesion with the depression circuit generated from the other lesion datasets, was significantly higher for depressed subjects than control subjects.