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. 2020 Sep 18;7:571092. doi: 10.3389/fmolb.2020.571092

FIGURE 1.

FIGURE 1

Overview of metabolites related to FMR1 premutation. Altered metabolites identified in studies of plasma from FMR1 premutation carriers are shown in bold and in black. Altered metabolites identified in studies of FXTAS mice cerebellum are show in bold and in red. The up arrow indicates the increase, and the down arrow indicates the decrease. The “shunt” refers to the pentose phosphate shunt. The glycolysis pathway is outlined in red, with the pentose phosphate shunt outlined in a dashed red box. The TCA cycle is outlined in solid blue, and GABA metabolism is outlined in a dashed blue circle. Purine metabolism is outlined in purple, synthesis of polyunsaturated fatty acids is outlined in green, and sphingolipid metabolism is outlined in orange. AA, arachidonic acid; ALA, α-linolenic acid; AMP, Adenosine monophosphate; CoA, Coenzyme A; DHA, docosahexaenoic acid; DHGLA, dihomo-γ-linolenic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; FAD, Flavin adenine dinucleotide; GABA, γ-Aminobutyric acid; GHB, 4-hydroxybutyrate; GLA, Gamma linolenic acid; Gln, Glutamine; Glu, Glutamate; GMP, Guanosine monophosphate; IMP, Inosine monophosphate; LA, linoleic acid; LTB4, Leukotriene B4; MUFAs, monounsaturated fatty acids; NAD+, Nicotinamide adenine dinucleotide; PGA1, Prostaglandin A1; PGE2, Prostaglandin E2; PGF2a, Prostaglandin F2alpha; PGI2, prostaglandin I2; PUFAs, polyunsaturated fatty acids; SFAs, saturated fatty acids; SSA, succinic semialdehyde; TXA2, Thromboxane A2; XMP, Xanthosine monophosphate.