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. 2020 Oct 2;15(10):e0240154. doi: 10.1371/journal.pone.0240154

Fig 4. Effect of HIV, HPV and HPV-associated pathology on frequencies of HLA-DR+ T cells.

Fig 4

A, B, C: Comparison of the frequencies of HLA-DR+ CD4 (A), HLA-DR+CCR5+ α4β7+ CD4 (B) and HLA-DR+ CD8 (C) T cells on HIV- (n = 129) vs HIV+ (n = 126) women and HPV- (n = 33) vs HPV+ (n = 70). The frequency of HLA-DR+ cells is shown as percent of CD4, CCR5+ α4β7+ CD4 or CD8 T cells in relation to HIV and HPV status. D,E: Comparison of the percentage of HLA-DR+ cells in CD4 (D) and CD8 (E) T cells in relation to different permutations of HIV and cervical lesion (n = 237; HIV+ Lesion- = 92, HIV+ Lesion+ = 24, HIV- Lesion- = 98, HIV- Lesion+ = 23). F: Negative correlation of HLA-DR+CD4+ cervical T cell frequencies with peripheral blood absolute CD4 T-cell counts in HIV+ women (n = 113, r = -0.3111, p < 0.001). Median frequencies, correlation coefficient, and p-values are indicated in the graphs. Statistical analyses were performed using Mann-Whitney U-test (Fig 4A–4E) and Spearman correlation test (Fig 4F).