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. 2020 Sep 22;16(9):e1008244. doi: 10.1371/journal.pcbi.1008244

Table 1. Groups of statistically significant (p_value < 0.001) upstream diagnoses ranked according to their MCC values.

For each diagnosis, we show its values for MCC (Matthews Correlation Coefficient), OR (Odds Ratio), OR_CI (its confidence interval) and COV (Coverage).

ICD10 code MCC OR 99.9% OR_CI COV
1. Diagnoses related to liver dysfunction
Fibrosis and cirrhosis of liver 0.28 140.99 80.51-246.87 943
Ascites 0.28 67.63 45.83-99.81 977
Other diseases of digestive system 0.26 26.03 20.21-33.54 1,007
Oesophageal varices 0.25 141.21 74.00-269.44 727
Other diseases of liver 0.17 40.71 24.75-67.46 388
Hepatic failure, not elsewhere classified 0.16 67.97 33.85-136.48 326
Chronic viral hepatitis 0.13 20.24 12.86-31.86 269
2. Diagnoses related to alcohol-overuse
Mental-behavioral disorders due to alcohol 0.44 20.25 17.87-22.94 3,075
Other diseases of pancreas 0.13 10.30 7.60-13.96 364
Other and unspecified polyneuropathies 0.12 19.36 12.19-30.75 250
Symptoms and signs involving appearance and behaviour 0.02 19.32 1.43-260.6 8
3. Diagnoses related to malnutrition
Other anaemias 0.18 8.63 7.07-10.54 748
4. Diagnoses related to trauma and injuries
Fracture 0.13 2.68 2.41-2.98 1,709
Superficial injuries 0.10 2.28 2.02-2.57 1,215
Open wound 0.09 2.19 1.94-2.46 1,269
5. Diagnoses related to upper intestinal mucosal
Gastritis and duodenitis 0.17 11.01 8.57-14.14 560
Gastric ulcer 0.14 9.68 7.31-12.82 410
Duodenal ulcer 0.12 9.64 6.98-13.32 310
Oesophagitis 0.11 10.96 7.44-16.13 235
6. Others
abdominal and pelvic pain 0.10 3.56 2.96-4.27 578